First Baptist Church of Ironton is affiliated with the Southern Baptist Convention. FBC Ironton cooperates with other Southern Baptist churches on the local level (Mineral Area Baptist Association), the state level (Missouri Baptist Convention), and the national level (Southern Baptist Convention).

FBC Ironton partners with Southern Baptist churches for the purpose of local and global missions and education through colleges and seminaries. FBC Ironton practically supports missions and education by contributing to the Cooperative Program, the Southern Baptist funding mechanism, and by participating in missions and education endeavors with Southern Baptist agencies.